LYMPHOID NEOPLASIA Brief report Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor?
نویسندگان
چکیده
Hervé Avet-Loiseau,1 Florent Malard,1 Loic Campion,2 Florence Magrangeas,1 Catherine Sebban,3 Bruno Lioure,4 Olivier Decaux,5 Thierry Lamy,6 Laurence Legros,7 Jean-Gabriel Fuzibet,8 Mauricette Michallet,9 Bernadette Corront,10 Pascal Lenain,11 Cyrille Hulin,12 Claire Mathiot,13 Michel Attal,14 Thierry Facon,15 Jean-Luc Harousseau,16 Stephane Minvielle,1 and Philippe Moreau,17 for the Intergroupe Francophone du Myélome
منابع مشابه
Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor?
Many trials in myeloma are stratified on cytogenetic abnormalities. Among them, the most commonly chosen are the t(4;14), the del(17p), and the t(14;16). If data are well established for t(4;14) and del(17p), very few data support the use of t(14;16). To address this issue, we retrospectively analyzed 1003 patients with newly diagnosed myeloma for this abnormality. We identified 32 patients wit...
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Routine incorporation of FISH into multiple myeloma (MM) diagnostic testing has led to a better appreciation of the heterogeneity of genetic abnormalities associated with this disease. We studied a group of 484 patients with newly diagnosed symptomatic MM to better understand the prevalence of the various abnormalities and the prognostic significance of the overlapping abnormalities. A transloc...
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BACKGROUND Light chain amyloidosis is a rare plasma cell dyscrasia. Interphase fluorescence in situ hybridization (FISH) coupled to cytoplasmic staining of specific Ig (cIg-FISH) on bone marrow plasma cells has become well established in the initial evaluation of multiple myeloma, a related disorder. Little, however, is known about cytogenetic abnormalities in patients with light chain amyloido...
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A paucity of validated kinase targets in human multiple myeloma has delayed clinical deployment of kinase inhibitors in treatment strategies. We therefore conducted a kinome-wide small interfering RNA (siRNA) lethality study in myeloma tumor lines bearing common t(4;14), t(14;16), and t(11;14) translocations to identify critically vulnerable kinases in myeloma tumor cells without regard to prec...
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Genetic abnormalities in patients with multiple myeloma (MM) are important risk factors in terms of prognosis. In the present study, the prognostic value of several common MM genetic abnormalities was investigated. Interphase fluorescence in situ hybridization (iFISH) was used to detect genetic abnormalities, including 1q21 gain, t(4;14), t(11;14), t(14;16) and 17p13 deletion in 131 patients. A...
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